Air oxidation of oxindoles to isatins

Details Air oxidation of oxindoles to isatins Air oxidation of oxindoles to isatins

C - Chemistry, Metallurgy

07

D

260/319

C07D 209/38 (2006.01)

Patent

CA 1133493

ABSTRACT OF THE DISCLOSURE An aniline is converted to a 3-lower hydrocarbon- thiooxindole by processes already known in the art and then air oxidized in an inert liquid vehicle in the presence of a base. The inert liquid vehicle advantageously is aprotic and the base is non-nucleophilic. Also, the aprotic liquid vehicle is desirably solvent for the starting 3-lower hydrocarbonthiooxindole and the non-nucleophilic base.

343440

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