Akt protein kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/04 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2546754

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

L'invention concerne des composés, comprenant des énantiomères, diastéréomères, solvates résolus ainsi que des sels pharmaceutiquement acceptables de ceux-ci. Ces composés comprennent la formule: A-L-CR, dans laquelle CR représente un groupe central cyclique, L représente un groupe de liaison et A est tel que défini dans le descriptif. L'invention concerne également des procédés permettant d'utiliser ces composés en tant qu'inhibiteurs de la protéine kinase AKT ainsi que pour le traitement de maladies hyperprolifératives telles que le cancer.

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