Albumin binding sites for evaluating drug interactions and...

G - Physics – 06 – F

Patent

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G06F 17/11 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2565308

A method is provided for evaluating drug compounds based on their binding properties to human serum albumin wherein structural information at particular albumin binding regions is entered into a computer database and assessed with regard to particular contacting binding residues located in accordance with the invention. The information obtained through the computer database is thus useful in assessing and predicting drug interactions at albumin binding sites. Further, protein fragments including one or more albumin binding sites are provided which can be used in methods of assessing and designing drugs.

L'invention concerne un procédé d'évaluation de composés médicamenteux en fonction de leurs propriétés de fixation au sérum-albumine, méthode dans laquelle les informations structurelles sur des zones de liaison sur l'albumine particulières sont entrées dans une base de données informatique et sont évaluées par rapport à des restes de liaison de contact situés selon l'invention. Les informations obtenues par la base de données informatique sont ainsi utiles dans l'évaluation et la prédiction d'interactions médicamenteuses au niveau de sites de fixation sur l'albumine. De plus, des fragments protéiques comprenant un ou plusieurs sites de liaison sur l'albumine pouvant être utilisés dans des procédés d'évaluation et de conception de médicaments sont décrits.

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