C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/76 (2006.01) C07K 14/765 (2006.01)
Patent
CA 2557174
The invention relates to an albumin-purification method comprising a step consisting in subjecting an aqueous albumin solution, with a concentration of between 15 g/l and 80 g/l and a pH of not less than 7, to nanofiltration in a temperature range of between 15 ·C and 55 ·C. The invention also relates to: a virally-safe aqueous albumin solution which can be obtained using the inventive method and in which the sites for the transport and binding of the active therapeutic ingredients of the albumin are available; and an albumin composition for therapeutic use, which is obtained by adapting the albumin solution that is intended for clinical use.
L~invention concerne un procédé de purification d~albumine comprenant une étape consistant à soumettre une solution aqueuse d~albumine, de concentration 15 g/l à 80 g/l et de pH non inférieur à (7), à une nanofiltration dans une plage de température allant de 15 ~C à 55 ~C. L~invention concerne également une solution aqueuse d~albumine viralement sécurisée susceptible d~être obtenue par la mise en .oelig.uvre du procédé, dans laquelle les sites de transport et de fixation de principes actifs thérapeutiques de l~albumine sont disponibles et une composition d~albumine à usage thérapeutique obtenue par un traitement d~adaptation de ladite solution d~albumine à un usage clinique.
Boulange Paul
Boyer Stephane
Chtourou Sami
Padrazzi Bruno
Schmitthaeusler Roland
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
Robic
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