Alcam and alcam modulators

Details Alcam and alcam modulators Alcam and alcam modulators

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2483912

Provided herein is disclosure about the discovery that the known antigen, ALCAM, is present on a variety of human cancers other than metastasizing malignant melanoma. Also disclosed herein are methods of diagnosing and treating cancers that express ALCAM by using antibodies directed against ALCAM. This invention also discloses compositions and methods for the modulation of ALCAM-mediated neovascularization.

L'invention concerne une découverte qui porte sur un agent connu, ALCAM, présent dans la plupart des cancers chez l'homme autres que le mélanome à métastases malin. Elle concerne aussi des procédés pour diagnostiquer et traiter les cancers qui expriment ALCAM en utilisant des anticorps dirigés contre ALCAM. Cette invention porte aussi sur des compositions et des procédés pour moduler la néovascularisation à médiation par ALCAM.

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