Alcohol and ether derivatives

Details Alcohol and ether derivatives Alcohol and ether derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/297

C07C 43/20 (2006.01) A61K 31/085 (2006.01) C07C 43/178 (2006.01) C07C 43/205 (2006.01) C07C 43/215 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 43/315 (2006.01) C07C 45/00 (2006.01) C07C 45/59 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 49/255 (2006.01) C07C 49/84 (2006.01) C07C 59/68 (2006.01) C07C 255/37 (2006.01) C07C 323/16 (2006.01) C07D 213/65 (2006.01) C07D 303/22 (2006.01) C07D 307/12 (2006.01) C07D 319/06 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2006094

A B S T R A C T TITLE: ALCOLOL AND ETHER DERIVATIVES The invention concerns a compound of the formula I, I Image wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; Ar2 is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1- 4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; wherein R2 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; and wherein R3 is hydroxy-(1-4C)alkyl, mercapto-(1-4C)alkyl, (1-4C)alkoxy- (1-4C)alkyl, (3-4C)alkenyloxy-(1-4C)alkyl, (3-4C)alkynyloxy-(1- 4C)alkyl, (1-4C)alkoxy-(2-4C)alkoxy-(1-4C)alkyl, (1-4C)alkylthio-(1- 4C)alkyl, (1-4C)alkylsulphinyl-(1-4C)alkyl, (1-4C)alkylsulphonyl-(1- 4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C)alkyl, (2-4C)alkanoyl-(1- 4C)alkyl, (2-4C)alkanoyloxy-(1-4C)alkyl or cyano-(1-4C)alkyl; or R3 is oxiranyl, oxetanyl, tetrahydrofuranyl or tetrahydropyranyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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