Alcohol or aldehyde derivatives and their use

Details Alcohol or aldehyde derivatives and their use Alcohol or aldehyde derivatives and their use

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/16 (2006.01) A61K 31/265 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) A61K 38/55 (2006.01) C07C 233/18 (2006.01) C07C 233/22 (2006.01) C07C 233/31 (2006.01) C07C 233/46 (2006.01) C07C 271/16 (2006.01) C07C 271/18 (2006.01) C07C 271/22 (2006.01) C07C 311/19 (2006.01) C07D 209/16 (2006.01) C07D 209/20 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2115913

Abstract of the Disclosure The present invention provides a cathepsin h inhibitor containing a compound of the formula: Image (I) wherein R1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R2 and R3 independently are a hydrogen atom or a hydrocarbon residue which may be substituted; R4 is an alkanoyl, sulfonyl, carbonyloxy, carbamoyl or thiocarbamoyl group which may be substituted; X is formula: -CHO or -CH2OB (wherein B is a hydrogen atom or a protecting group of hydroxyl group); m and n independently are an integer of 0 or 1; provided that R4 is an alkanoyl group substituted by aryl, a sulfonyl group substituted by aryl having more than 9 carbon atoms or by lower alkyl, or a carbamoyl or thiocarbamoyl group which may be substituted when R1 is an unsubstituted lower alkyl, arylalkyl on methylthioethyl group, R2 and R3 independently are a lower alkyl or arylalkyl, X is -CHO, m is 1 and n is 0 or 1, or a salt thereof. Compound (I) is useful as a prophylactic/therapeutic agent for osteoporosis.

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