Aldehyde conjugated flavonoid preparations

C - Chemistry – Metallurgy – 08 – B

Patent

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Details

C08B 37/08 (2006.01) A61K 31/353 (2006.01) A61K 47/48 (2006.01) C08G 65/331 (2006.01)

Patent

CA 2606583

There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.

La présente invention concerne une méthode de conjugaison d'un polymère contenant un groupement aldéhyde libre avec un flavonoïde en présence d'un catalyseur acide, de façon à ce que le polymère soit conjugué à la position C6 ou C8 du cycle A du flavonoïde. Les substances conjuguées résultantes peuvent être employées pour élaborer des vecteurs permettant la libération de doses élevées de flavonoïdes, et peuvent également être employées en tant que vecteurs pour la libération d'un agent bioactif supplémentaire.

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