Aldehyde oxidase inhibitors for treatment of aids

Details Aldehyde oxidase inhibitors for treatment of aids Aldehyde oxidase inhibitors for treatment of aids

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01) A61K 31/70 (2006.01) A61K 31/7072 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2255325

A new pathway of metabolism of 3'-azido-3'- deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine (AMT) has been described. This pathway involves the enzyme aldehyde oxidase. Aldehyde oxidase inhibitors may be used to reduce AMT formation during therapy with AZT.

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