C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/36 (2006.01) A61K 31/352 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2653056
Disclosed are novel isoflavone derivatives having the structure of Formula (I) which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
La présente invention concerne de nouveaux dérivés d'isoflavone dont la structure répond à la formule (I). Les dérivés se révèlent utiles en tant qu'inhibiteurs de l'aldéhyde déshydrogénase (ALDH-2) pour le traitement de mammifères présentant une accoutumance à des substances susceptibles d'induire une dépendance, par exemple une accoutumance à un agent produisant de la dopamine tel que la cocaïne, la morphine, les amphétamines, la nicotine, et l'alcool.
Abelman Matthew
Arolfo Maria Pia
Bilokin Yaroslav
Diamond Ivan
Elzein Elfatih
Cv Therapeutics Inc.
Gilead Palo Alto Inc.
Mbm Intellectual Property Law Llp
The Endowment For Research In Human Biology Inc.
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