Aldh-2 inhibitors in the treatment of addiction

Details Aldh-2 inhibitors in the treatment of addiction Aldh-2 inhibitors in the treatment of addiction

C - Chemistry, Metallurgy

07

D

C07D 311/36 (2006.01) A61K 31/353 (2006.01) A61P 25/32 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2712750

Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

La présente invention concerne de nouveaux dérivés d'isoflavone, dont la structure est représentée par la formule (I), qui se révèlent utiles en tant qu'inhibiteurs d'ALDH-2 pour traiter des mammifères qui dépendent de substances créant un effet d'accoutumance, par exemple l'accoutumance à un agent produisant de la dopamine tel que la cocaïne, la morphine, les amphétamines, la nicotine et l'alcool.

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