C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2329506
The invention provides isolated nucleic acids molecules, designated hALG-2LP, sALG-2LP, and mALG-2LP nucleic acid molecules, which encode proteins involved in the modulation of programmed cell death. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hALG-2LP, sALG-2LP, and mALG-2LP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a hALG-2LP, sALG-2LP, and mALG-2LP gene has been introduced or disrupted. The invention still further provides isolated hALG-2LP, sALG-2LP, and mALG-2LP proteins, fusion proteins, antigenic peptides and anti-hALG-2LP, sALG-2LP, and mALG-2LP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
La présente invention porte sur des molécules d'acides nucléiques isolées, appelées molécules d'acide nucléique hALG-2LP, sALG-2LP, et mALG-2LP, qui codent des protéines impliquées dans la modulation de la mort cellulaire programmée; des molécules d'acide nucléique antisens, des vecteurs d'expression de recombinaison contenant les molécules d'acide nucléique hALG-2LP, sALG-2LP et mALG-2LP, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène hALG-2LP, sALG-2LP ou mALG-2LP a été introduit ou interrompu; des protéines isolées hALG-2LP, sALG-2LP, et m ALG-2LP, des protéines de fusion, des peptides antigéniques et des anticorps anti-hALG-2LP, sALG-2LP et mALG-2LP; ainsi que sur des procédés de diagnostic dans lesquels on utilise les compositions de cette invention.
Borden Ladner Gervais Llp
Millennium Pharmaceuticals Inc.
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