Alginate microcapsules, methods of making and using same

Details Alginate microcapsules, methods of making and using same Alginate microcapsules, methods of making and using same

A - Human Necessities

61

L

167/327

A61L 27/00 (2006.01)

Patent

CA 2034633

Improved Alginate Microcapsules Methods of Making and Using Same Abstract A composition for containing biological material for in vivo implantation and transplantation comprising alginate cross-linked with barium salt, preferably barium chloride. The microcapsule may optionally have as its other layers hyaluronic acid and poly-L-lysine. Also alginate cross-linked with both calcium chloride and barium chloride may be used. The microcapsule of the present invention is rugged and retains a strong negative charge, enhancing the release of protein and limiting the invasion of immunoglobulins. The microcapsule may preferably be used for encapsulating islets of Langerhans for the production of insulin.

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