C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) G06F 19/12 (2011.01) C12N 9/99 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2735937
The invention is an algorithm and method for designing an inhibitor that covalently binds a target polypeptide. The algorithm and method can be used to rapidly and efficiently convert reversible inhibitors into irreversible inhibitors.
La présente invention concerne un algorithme et un procédé pour concevoir un inhibiteur se liant de manière covalente à un polypeptide cible. Ces algorithmes et procédé peuvent être utilisés pour transformer rapidement et efficacement des inhibiteurs réversibles en inhibiteurs irréversibles.
Niu Deqiang
Petter Russel Colyn
Singh Juswinder
Avila Therapeutics Inc.
Gowling Lafleur Henderson Llp
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