C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C40B 30/00 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2617487
Create an algorithm to manage one or multiple genes (and multiple levels of cascading genes that must also be turned on or off (activate) or are turned on or off (activate) by the initial levels of genes being turned on or off) from same group associated to a desired trait. To isolate this specific network may take analyzing a few to 1,000s of genes. We could use cloning techniques to produce the muscle tissue, nerves (neurons), any specialized cells of subjects possessing trait and not possessing the trait. Then: 1. We could search for genes in one tissue culture where the trait is present versus the genes where the tissue culture trait is not present. Checking where the group of associated genes are turned on or off and the opposite where the trait is present one and not present in the other. We could use micro arrays to speed up the process. 2. We use micro arrays to the genes in the 1000's at time, to see if turning off or on one gene has a (i) a direct effect on the trait or (ii) if other genes (are turned on or off (activate) by the change in the first gene - precursor) in the associated group has a cascading effect on other genes that are then responsible for effecting the trait. We might also want to check if there is a feedback loop, where the process might cascade backwards. (iii) Multiple genes might have to be turned off and/or (activate/deactivating) on at the same time to attain the desired trait. (iv) Turning on or off a gene which may block or unblock the effect of another gene's capability to (through turning on or off this gene - activate/deactivating) affect/impact the targeted trait (last line; GV + JW). 3. While testing these genes it may be a good idea (i) to be on the lookout for other (useful - such as similar hereditary disease cures) traits that may be impacted/affects by any of the genes in the network being turned on or off (activate). (ii) Traits may also impacted/affects that were not initially targeted but are nonetheless targeted. (iii) Finally the gene may have an effect that is difficult to observe or the gene may just do nothing. 4. We are considering using epigenetic drugs to turn or off these genes or other forms of gene therapy also genetic engineering cloning for DNA nucleus stem cells. We also plan to study how enzymes, density cells nearby, cells (cell to cell signalling) hormones and proteins (bis peptides), Ligase (ase's), grafting and manipulating of nucleotide or nucleotide networks, that can work in conjunction to impact cell and its functioning to cure hereditary diseases and alter genes of bacteria/viruses (antibiotic resistant or virulent strains) that are a threat to the human body's health. 5. Once we have identified the gene schematics that control the trait, we can stay on top of this associated group of genes (for example in the case of antibiotic resistant and virulent bacteria/viruses to check this associated group if any new mutations emerge again in the future).(JW)
Na
Voon Gerard
LandOfFree
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