Alicyclic acylated heterocyclic derivatives

Details Alicyclic acylated heterocyclic derivatives Alicyclic acylated heterocyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 265/30 (2006.01) C07D 265/32 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07D 417/14 (2006.01) C07D 491/107 (2006.01) C07D 495/10 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2312770

Compounds represented by general formula (1) and having a selective antagonism to NK2 receptors and pharmacologically acceptable salts or derivatives thereof, wherein R1 represents optionally substituted cycloalkyl or an optionally substituted saturated heterocycle; R2 represents aryl, etc.; A represents methylene, etc.; B represents a single bond, alkylene, etc.; D represents oxygen or sulfur; G represents alkylene, etc.; L represents -N(R3)- or -C(R4)(R5)- [wherein R3 represents aryl, etc.; R4 represents aryl, etc.; and R5 represents optionally aminated alkyl or -CO-R6 (wherein R6 represents alkyl, etc.); or R4 and R5 may form together a cycloalkane ring, etc.]; R7 represents alkyl; Z represents two hydrogen atoms or an oxygen atom; and n is 0, 1 or 2.

L'invention concerne des composés de formule générale (1) possédant un antagonisme sélectif vis-à-vis des récepteurs de NK¿2?, ainsi que les sels pharmaceutiquement acceptables de ces dérivés. Dans ladite formule, R?1¿ est cycloalkyle éventuellement substitué ou un hétérocycle saturé éventuellement substitué; R?2¿ est aryle, etc.; A est méthylène, etc.; B est une liaison unique, alkylène, etc.; D est oxygène ou soufre; G est alkylène, etc.; L est -N(R?3¿)- ou -C(R?4¿)(R?5¿)- [sachant que R?3¿ est aryle, etc.; R?4¿ est aryle, etc.; et R?5¿ est alkyle éventuellement aminé ou -CO-R?6¿ (R?6¿ étant alkyle, etc.), ou R?4¿ et R?5¿ peuvent former ensemble une chaîne cycloalcane, etc.]; R?7¿ est alkyle; Z représente deux atomes d'hydrogène ou un atome d'oxygène; et n vaut 0, 1 ou 2.

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