C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/22 (2006.01) A61K 31/33 (2006.01) A61P 3/00 (2006.01) C07D 471/18 (2006.01) C07D 491/18 (2006.01)
Patent
CA 2724214
The present invention relates to compounds defined by Formula (I), wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 .beta.-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
La présente invention concerne des composés définis par la formule (I) présentant une activité pharmacologique utile. Dans ladite formule, les groupes A, B, X, m, n et o sont tels que définis dans la revendication 1. En particulier, les composés de linvention sont des inhibiteurs de la 11ß-hydroxystéroïde déshydrogénase (HSD) 1 ; ils sont ainsi adaptés au traitement et à la prévention de maladies qui peuvent être influencées par linhibition de cet enzyme, telles que les maladies métaboliques, et notamment le diabète de type 2, lobésité et la dyslipidémie.
Eckhardt Matthias
Hamilton Bradford S.
Himmelsbach Frank
Kley Joerg
Lehmann-Lintz Thorsten
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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