Aliphatic amine polymer salts for tableting

Details Aliphatic amine polymer salts for tableting Aliphatic amine polymer salts for tableting

A - Human Necessities

61

K

A61K 31/785 (2006.01) A61K 9/20 (2006.01) A61K 31/787 (2006.01) A61P 3/12 (2006.01)

Patent

CA 2586023

The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion canprevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37~C and at pH of at least 1 for a period of at least ten weeks at 60 ~C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.

La présente invention concerne des comprimés, des compositions et des procédés. Lesdits comprimés, qui contiennent un sel carbonate d'un polymère d'amine aliphatique et un anion monovalent, peuvent prévenir ou améliorer l'acidose, en particulier l'acidose chez des patients souffrant de néphropathies. Les comprimés et compositions selon la présente invention conservent une durée de désintégration ne dépassant pas 30 minutes à 37 °C et à un pH d'au moins 1 lorsqu'ils sont stockés pendant au moins dix semaines à 60 °C. De plus, lesdits comprimés sont stables pendant une période prolongée, sans nécessiter des conditions de stockage spéciales.

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