Aliphatic carboxamides

Details Aliphatic carboxamides Aliphatic carboxamides

C - Chemistry, Metallurgy

07

D

167/207, 260/279

C07D 209/04 (2006.01) A61K 31/40 (2006.01) C07D 209/08 (2006.01) C07D 209/18 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01)

Patent

CA 1332835

This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z-Y-X< is selected from >C=CH-N<, >N-CH=C<, >C=N-N< and >N-N=C< and the other radicals have the meanings defined in the following specifica- tion. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceuti- cally acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture. Image I

564341

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