Aliphatic esters as a solventless coating for pharmaceuticals

Details Aliphatic esters as a solventless coating for pharmaceuticals Aliphatic esters as a solventless coating for pharmaceuticals

A - Human Necessities

61

K

A61K 47/14 (2006.01) A61K 9/16 (2006.01) A61K 9/30 (2006.01)

Patent

CA 2082137

A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50°-100°C) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.

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