C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/23 (2006.01) A61K 31/131 (2006.01)
Patent
CA 2295483
The present invention relates to the use of a group of propargylamines of general formula (I) wherein R1 is hydrogen or CH3 and R2 is (CH2)n CH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula (I) are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.
L'invention concerne l'utilisation d'un groupe de propargylamines de la formule générale (I) dans laquelle R<1> est hydrogène ou CH3 et R<2> est (CH2)nCH3 et n est un entier compris entre 0 et 16, et de sels dudit groupe, qui s'emploient comme antidotes électifs dans le traitement ou la prévention de maladies dans lesquelles la dégénerescence neuronale survient par apoptose. Certains des composés de la formule (I) sont nouveaux. L'invention concerne en outre des procédés de préparation desdits composés et leur utilisation dans le traitement desdites maladies.
Boulton Alan A.
Davis Bruce A.
Durden David A.
Dyck Lillian E.
Li Xin-Min
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Saskatchewan
University Of Saskatchewan Technologies Inc.
LandOfFree
Aliphatic propargylamines as cellular rescue agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aliphatic propargylamines as cellular rescue agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aliphatic propargylamines as cellular rescue agents will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2016371