Aliphatic thioethers

C - Chemistry – Metallurgy – 07 – C

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C07C 321/24 (2006.01) A61K 31/195 (2006.01) C07C 321/20 (2006.01) C07D 309/12 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1276393

Aliphatic thioethers Abstract Novel asymmetric thioethers of the formula Image (I) in which R1 represents a C1-3-alkyl radical or a C1-3-hydroxyalkyl radical of which the hydroxy group may be in esterified form, R2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms, R3 represents hydroxy, alkoxy or an optionally substituted amino group, and -X- represents a single bond, a methylene group or an optionally N-acylated primary aminomethylene group wherein the O-atom of the hydroxy group is in the trans- configuration relative to the S-atom, are effective as leucotriene-antagonists since they eliminate the contractions of smooth muscles caused by leucotrienes and are therefore suitable for the treatment of allergic, especially asthmatic, conditions.

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