Alk1 receptor and ligand antagonists and uses thereof

Details Alk1 receptor and ligand antagonists and uses thereof Alk1 receptor and ligand antagonists and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01)

Patent

CA 2668411

In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALKl) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALKl and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.

Certains aspects de cette invention concernent un procédé selon lequel un polypeptide comprenant une portion de liaison au ligand du domaine extracellulaire du polypeptide de la kinase de type activine (ALKI) peut être utilisé pour bloquer l'angiogénèse in vivo, en particulier chez des mammifères souffrant d'affections associées à l'angiogénèse. Cette invention concerne également des ligands pour ALKI ainsi qu'un procédé prouvant que ces ligands ont une activité pro-angiogénique, ainsi que des anticorps bloquant l'interaction récepteur-ligand.

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