Alkali metal salt of thiazolidine-2,4-dione derivatives

Details Alkali metal salt of thiazolidine-2,4-dione derivatives Alkali metal salt of thiazolidine-2,4-dione derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01)

Patent

CA 2401276

A method of industrially advantageously purifying 5-[(2,4-dioxothiazolidin-5- yl)methyl]-2-methoxy-N-[4-(trifluoromethyl)phenylmethyl]benzamide (KRP-297), which improves insulin resistance and is highly effective in lowering blood sugar and in lipid diminution. The method comprises the steps of: forming an alkali metal salt of KRP-297 and a hydrate thereof in a reaction system for producing KRP-297; isolating and purifying them; and then liberating the KRP- 297 from the salt. Also provided are an alkali metal salt of KRP-297 and a hydrate of the salt.

Cette invention concerne un procédé avantageux de purification industrielle de 5-[(2,4-dioxothiazolidine-5-yl)méthyle]-2-méthoxy-N-[4-(trifluorométhyl)phénylméthyl]benzamide (KPR-297) qui améliore la résistance insulinique et contribue très efficacement à abaisser la glycémie et à réduire les lipides. Ce procédé consiste à : former un sel de métal alcalin de KPR-297 et un hydrate de ce sel dans un système de réaction permettant de produire du KPR-297 ; les isoler et les purifier ; et libérer le KPR-297 du sel. L'invention concerne également un sel de métal alcalin de KPR-297 et un hydrate de ce sel.

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