C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/08 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2539755
The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, nc gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibrornyalgia, pain, diabetic neuropathy, and combinations thereof.
La présente invention concerne des dérivés d'alcanoyle et de cycloalcanoylamine, des compositions contenant ces dérivés, et des méthodes permettant de les utiliser pour prévenir et traiter des états pathologiques améliorés par la réabsorption de monoamines, y compris, entre autres, les symptômes vasomoteurs (VMS), la dysfonction sexuelle, les troubles gastro-intestinaux et génito-urinaires, le syndrome de fatigue chronique, le syndrome de fibromyalgie, les troubles du système nerveux, et des combinaisons de ceux-ci, plus particulièrement, les états pathologiques choisis dans le groupe comprenant le trouble dépressif majeur, les symptômes vasomoteurs le stress et l'incontinence urinaire par impériosité, la fibromyalgie, la douleur, la neuropathie diabètique, et des combinaisons de ces états.
Gavrin Lori Krim
Mahaney Paige Erin
Moore William Jay
Sabatucci Joseph Peter
Trybulski Eugene John
Torys Llp
Wyeth
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