Alkanolamine derivatives

Details Alkanolamine derivatives Alkanolamine derivatives

C - Chemistry, Metallurgy

07

D

260/246, 260/268

C07D 241/26 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1198110

ABSTRACT Novel alkanolamine derivatives of the formula:- Image wherein Ar is phenyl or naphthyl which is unsubstituted or which bears one or two substituents selected from halogen, trifluoromethyl, hydroxy, amino, nitro, carbamoyl, carbamoylmethyl and cyano, and alkyl, alkenyl, alkoxy, alkenyloxy, alkylthio, alkanoyl and alkanoylamino each of up to 6 carbon atoms, or Ar is 4-indolyl, 4-benzo[b]thienyl, 5-benzo[1,4]dioxanyl, 4- or 5-indanyl, 5- or 6- (1,2,3,4- tetrahydronaphthyl), 2,3-dihydxoxy-1,2,3,4-tetrahydro- naphth-5-yl or 4- morpholino-1,2,5-thiadiazol-3-yl; wherein R is halogen; wherein A1 is alkylene of 2 to 6 carbon atoms; and wherein A2 is alkylene of 1 to 7 carbon atoms which in unsubstituted or bears a phenyl, hydroxy or carbamoyl substituent, or A2 is cycloalkylene of 3 to 6 carbon atoms; or acid-addition salts thereof. The compounds possess either .beta.-adrenergic blocking activity or diuretic activity or both such activities and may be used in the treatment of heart disease or hypertension. Also disclosed are processes for the manu.acture of the compounds and pharmaceutical compositions containing them.

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