Alkenyl and alkynyl compounds as inhibitors of factor xa

Details Alkenyl and alkynyl compounds as inhibitors of factor xa Alkenyl and alkynyl compounds as inhibitors of factor xa

C - Chemistry, Metallurgy

07

C

C07C 311/46 (2006.01) A61K 31/18 (2006.01) A61P 7/02 (2006.01) C07C 311/51 (2006.01) C07D 217/22 (2006.01) C07D 239/94 (2006.01) C07D 307/54 (2006.01) C07D 401/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2362375

Published without an Abstract

L'invention porte sur des composés alcényle and alkynyle s'avérant de puissants inhibiteurs du facteur Xa isolés ou rassemblés dans le complexe de prothrombinase et sur des compositions contenant lesdits composés qui montrent une sélectivité vis à vis du facteur Xa supérieure à celle des autres protéases de la coagulation (par exemple la thrombine, le fVIIa, le fIXa) ou des cascades fibrinolytiques (par exemple les activateurs du plasminogène, la plasmine). L'invention porte également sur des procédés d'utilisation desdits composés comme agents de diagnostic ou thérapeutiques en vue de la prévention ou du traitement chez les mammifères de troubles de la coagulation tels que les thromboses.

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