Alkenyl- and alkynyl-containing metalloprotease inhibitors

Details Alkenyl- and alkynyl-containing metalloprotease inhibitors Alkenyl- and alkynyl-containing metalloprotease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/18 (2006.01) A61K 31/5375 (2006.01) A61P 19/02 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 311/42 (2006.01) C07C 311/46 (2006.01) C07C 311/47 (2006.01) C07C 323/58 (2006.01) C07C 323/67 (2006.01) C07D 207/337 (2006.01) C07D 209/42 (2006.01) C07D 213/55 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 285/135 (2006.01) C07D 295/088 (2006.01) C07D 295/092 (2006.01) C07D 295/145 (2006.01) C07D 295/155 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01)

Patent

CA 2364878

Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I) where X, W, Z, A, G, R1, R2, R3, R4, R5, R5' and k have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of said formula, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.

L'invention concerne des inhibiteurs des métalloprotéases, efficaces pour traiter des états caractérisés par une activité excessive de ces enzymes. L'invention concerne notamment des composés possédant une structure correspondant à la formule (I), dans laquelle X, W, Z, A, G, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?5'¿ et k possèdent les notations données dans la description. L'invention concerne également des isomères, diastéréomères et énantiomères optiques correspondant à la formule ci-dessus, ainsi que des sels de ceux-ci, acceptables sur le plan pharmacologique, et des amides, esters et imides biohydrolysables de ces composés. Elle concerne encore des procédés de traitement ou de prévention de maladies associées aux métalloprotéases, dans lesquels on utilise ces composés ou ces compositions pharmaceutiques.

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