Alkoxy-acyl carnitines, process for their preparation and...

Details Alkoxy-acyl carnitines, process for their preparation and... Alkoxy-acyl carnitines, process for their preparation and...

C - Chemistry, Metallurgy

07

C

260/488.8

C07C 229/22 (2006.01) A61K 31/14 (2006.01) A61K 31/195 (2006.01) A61K 31/205 (2006.01) A61K 31/22 (2006.01) A61K 31/24 (2006.01) A61K 31/265 (2006.01)

Patent

CA 1151208

"ALKOXY-ACYL CARNITINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME" ABSTRACT OF THE DISCLOSURES A novel class of alkoxy-acyl carnitines, wherein the alkoxy-acyl radical has from 4 to 6 carbon atoms (tipically: methoxypropionyl, ethoxypropionyl and propoxyacetyl) is prepared by reacting a solution of a carnitine salt in an organic solvent with an alkoxy- -acyl halogenide, thus obtaining the corresponding salt of alkoxy-acyl carnitine. By eluting an aqueous solution of this salt through a column of an ion exchange resin activated in Cl or Br form, the chloride or bromide of alkoxy-acyl carnitine is obtained. The alkoxy-acyl carnitines are therapeutically effective in the treatment of cardiac disorders, hyperlipidaemias and hyperlipoproteinaemias.

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