C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/41 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2083040
ABSTRACT OF THE DISCLOSURE This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cyclo- alkylalkyl and m is 1 or 2; R1 is alkyl of 1 to 4 carbon atoms; R2 is hydrogen or alkyl of 1 to 5 carbon atoms; R4 is alkyl of 1 to 6 carbon atoms; n is an integer from 1 to 5; and Y is NH or oxygen. The compounds of formula (I) are leukotriene B4 antagonists and are useful as anti-inflammatory agents and in the treatment of LTB4 mediated diseases.
Djuric Stevan Wakefield
Penning Thomas Dale
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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