Alkoxyamide derivatized chelates for mri

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 5/00 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07F 13/00 (2006.01) C07F 15/02 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2096543

2096543 9209884 PCTABS00013 Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

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