C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/80 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) A61P 13/02 (2006.01) A61P 29/00 (2006.01) C07C 271/28 (2006.01) C07D 239/26 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2438737
This invention relates to compounds which are generally IP receptor antagonists and which are represented by the general formula (I), wherein G1 is selected from the groups a, b1 and b2; (Formula a, b1 and b2) and A and G2 are as defined in the specification; or individual isomers, racemic or non- racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, their use as therapeutic agents, and methods of preparation thereof.
L'invention concerne des composés étant généralement des antagonistes des récepteurs IP et étant représentés par la formule générale (I), dans laquelle G?1¿ est sélectionné parmi les groupes <u>a</u>, <u>b?1¿</u> et <u>b?2¿</u>; (Formule <u>a</u>, <u>b?1¿</u> et <u>b?2¿</u>) et A et G?2¿ sont tels que définis dans la description; ou des isomères individuels, des mélanges racémiques ou non racémiques d'isomères, ou des sels ou solvants acceptables sur le plan pharmaceutique de ceux-ci. L'invention concerne en outre des compositions pharmaceutiques renfermant de tels composés, l'utilisation de ceux-ci comme agents thérapeutiques et des procédés de préparation de ceux-ci.
Lopez-Tapia Francisco Javier
Nitzan Dov
O'yang Counde
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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