C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 9/02 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 239/28 (2006.01)
Patent
CA 2438813
This invention relates to compounds which are IP receptor antagonists and which are represented by the general formula (1) wherein G2 is a heteroaryl group containing one or two nitrogen atoms and substituted with a carboxylic acid group, and G1 is as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, their use as therapeutic agents, and methods of preparation thereof.
L'invention concerne des composés antagonistes du récepteur d'IP représentés par la formule (I), dans laquelle G?2¿ représente un groupe hétéroaryle contenant un ou deux atomes de carbone et substitué par un groupe acide carboxylique et G?1¿ correspond à sa désignation du descriptif, ou isomères individuels, mélanges racémiques ou non racémiques d'isomères ou leurs sels ou solvates acceptables sur le plan pharmaceutique. Elle concerne, de plus, des compositions pharmaceutiques contenant ces composés, leur utilisation en tant qu'agents thérapeutiques et leurs procédés de préparation.
Lopez-Tapia Francisco Javier
Nitzan Dov
O'yang Counde
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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