Alkoxycoumarins substituted by a heterocyclic radical, their...

Details Alkoxycoumarins substituted by a heterocyclic radical, their... Alkoxycoumarins substituted by a heterocyclic radical, their...

C - Chemistry, Metallurgy

07

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167/207, 260/300

C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1330998

- 34 - Abstract of the Disclosure: An alkoxycoumarin sub- stituted by a heterocyclic radical, of the formula Image I R1 and R2 independently of one another are each hydrogen, C1-C5-alkyl, trifluoromethyl, phenyl or halogen, or together form a C3-C5-alkylene chain, R3 is C1-C5-alkyl or halogen, n is an integer of from 0 to 3, R4 is hydrogen or C1-C4-alkyl and Het is one of the following heterocyclic radicals: Image where X is oxygen or sulfur, R5 is unsubstituted or C1- C4-alkoxy-substituted C1-C10-alkyl, 5-membered or 6- membered oxacycloalkyl, C3-C7-cycloalkyl, benzyl, phenyl which is unsubstituted or substituted by halogen or NO2, a pyridine ring, C1-C5-alkoxycarbonyl or perfluoro-C1-C2- alkyl, R6 is C1-C5-alkyl or C1-C5-alkoxy, R7 is C1-C5-alkyl, unsubstituted or halogen-substituted benzyl or halogen, m is from 0 to 2, R8 is C1-C5-alkyl, C3-C8-cycloalkyl, benzyl or phenyl, R9 is hydrogen or C1-C5-alkyl, R10 is C1- C5-alkyl or C1-C8 cycloalkyl, R11 is C1-C5-alkyl, R12 is hydrogen, C1-C5-alkyl or C3-C6-cycloalkyl, R13 is C1-C5- alkyl or halogen, p is from 0 to 2, R14 is C1-C5-alkyl, q is 0 or 1, R15 and R16 are each hydrogen, C1-C5-alkyl or benzyl, R17 is hydrogen or C1-C5-alkyl and R18 is C1-C5- - 35 - alkyl, with the proviso that R5 is not phenyl when X is oxygen, R1 is methyl and R2 to R4 are each hydrogen, processes for their preparation and drugs prepared therefrom.

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