Alkoxypyridine derivatives as nitric oxide synthase inhibitors

Details Alkoxypyridine derivatives as nitric oxide synthase inhibitors Alkoxypyridine derivatives as nitric oxide synthase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) A61K 31/4427 (2006.01) A61K 31/52 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2480385

The compounds of formula (I) in which R1 is 1-4C-alkoxy, , A is 1-4C-alkylene, B represents 3H-imidazo (4,5b) pyridin-2-yl, 3H-imidazo (4,5-b) pyridin-2-yl substituted by R2 and/or R8, 9H-purin-8yl or 9H-purin-8-yl substituted by R4 and/or R5 are effective iNOS inhibitors.

L'invention concerne les composés de formule (I), dans laquelle R1 est C1-4 alcoxy, A est C1-4 alkylène, B représente 3H-imidazo (4,5-b) pyridin-2-yl, 3H-imidazo (4,5-b) pyridin-2-yl substitué par R2 et/ou R3, 9H-purine-8-yl ou 9H-purine-8-yl substitué par R4 et/ou R5, qui sont des inhibiteurs efficaces de iNOS.

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