C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/44 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 241/50 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 471/10 (2006.01) C07D 487/10 (2006.01) C07F 9/6509 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2219755
A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, Alzheimer's, Parkinson's, and Huntington's diseases.
L'invention concerne une nouvelle série de quinoxaline 2,3-diones substituées utilisées comme agents neuroprotecteurs. L'invention concerne également de nouveaux intermédiaires, des procédés de préparation et des compositions pharmaceutiques contenant ces composés. Ces composés sont des antagonistes du glutamate et ils sont utiles pour le traitement des ictus, des ischémies cérébrales, des infarctus cérébraux résultant d'attaques thromboemboliques ou hémorragiques, d'angiospasmes, de l'hypoglycémie, des arrêts cardiaques, de l'état de mal épileptique, de l'asphyxie périnatale, de l'anoxie, des maladies d'Alzheimer, de Parkinson et d'Huntington.
Kornberg Brian Edward
Nikam Sham Shridhar
Rafferty Michael Francis
Macrae & Co.
Warner-Lambert Company
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