C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/38 (2006.01) A61K 31/495 (2006.01) A61K 51/04 (2006.01) C07D 241/44 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2175795
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic latoral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, and inducing anesthesia are disclosed by administering to an animal in need of such treatment an alkyl or azido- substituted 1,4-dihydroquinoxaline-2,3-dione or pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.
L'invention concerne des procédés de traitement ou de prévention de baisses de l'activité neuronale associées aux ictus, à l'ischémie, aux traumatismes du système nerveux central, à l'hypoglycémie et aux opérations chirurgicales, ainsi que de traitement de maladies dégénératives du système nerveux, notamment la maladie d'Alzheimer, la sclérose latérale amyotrophique, la chorée de Huntington, et le mongolisme. L'invention concerne également le traitement ou la prévention des conséquences négatives de l'hyperactivité des acides aminés excitateurs, de même que le traitement de l'anxiété, des douleurs chroniques, des convulsions, et la manière d'induire l'anesthésie, par administration à un animal requérant ce type de traitement, d'une 1,4-dihydroquinoxaline-2,3-dione substituée par alkyle ou par azido ou de ses sels pharmaceutiquement acceptables, qui ont un pouvoir de fixation élevé sur le récepteur de la glycine.
Cai Sui Xiong
Keana John F.w.
Kher Sunil
Weber Eckard
Acea Pharmaceuticals Inc.
Mbm & Co.
Oregon State Of Oregon Acting By And Through The Oregon Stateboard Of H
The Regents Of The University Of California
LandOfFree
Alkyl, azido, alkoxy, and fluoro-substituted and fused... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alkyl, azido, alkoxy, and fluoro-substituted and fused..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkyl, azido, alkoxy, and fluoro-substituted and fused... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1763827