Alkyl ether analogs of chlorins having an n-substituted...

Details Alkyl ether analogs of chlorins having an n-substituted... Alkyl ether analogs of chlorins having an n-substituted...

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 41/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2335514

Compounds having generic formula (I), where R1, R2 and R3 are independently alkyl of 3 through about 10 carbon atoms; provided that, R1 and R2 together contain at least six carbon atoms. The compounds have utility in photodynamic therapy in treatment of tumors and other diseases. The invention includes a method of treatment by contacting a tumor with the compound and then exposing the tumor to light.

Cette invention se rapporte à des composés représentés par la formule générique (I), où R<1>, R<2> et R<3> représentent séparément alkyle contenant 3 à environ 10 atomes de carbone; à condition que R<1> et R<2> contiennent ensemble au moins six atomes de carbone. Ces composés ont une application dans la thérapie photodynamique de traitement des tumeurs et d'autres affections. Cette invention présente un procédé de traitement consistant à mettre une tumeur en contact avec un tel composé, puis à exposer la tumeur à un rayonnement lumineux.

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