Alkyl-linked nucleotide compositions

Details Alkyl-linked nucleotide compositions Alkyl-linked nucleotide compositions

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) B01D 15/08 (2006.01) B01D 15/38 (2006.01) B01J 20/281 (2006.01) B01J 20/289 (2006.01) C07H 19/04 (2006.01) C07H 19/10 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2513901

Alkyl-linked nucleotide compositions and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.

L'invention concerne des compositions de nucléotides à liaison alkyl et des substances à affinité pour les nucléotides contenant des nucléotides à liaison alkyl. Le lieur est générallement un lieur hydrophobe pouvant être une chaîne portant 3, 4, 5, 6, 7, 8, 9 ou 10 atomes de carbone ou plus. L'invention concerne également des procédés de synthèse d'un nucléotide à liaison alkyl, des substances à affinité pour les nucléotides, et des procédés d'utilisation de ceux-ci dans la chromatographie par affinité et des procédés de criblage.

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