Alkyl-substituted cellulose-based sustained-release oral...

Details Alkyl-substituted cellulose-based sustained-release oral... Alkyl-substituted cellulose-based sustained-release oral...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2132012

Sustained release oral drug dosage forms that comprise a tablet or capsule of a plurality of particles of a solid-state drug dispersed in alkyl cellulose such as hydroxyethylcellulose or hydroxypropylcellulose. Once ingested the tablet or capsule disinte- grates to disperse the particles into the stomach where they imbibe water to cause them to swell and also to become slippery, thus enhancing their retention in the stomach. Imbibed water from the gastric fluid dissolves the drug entrapped in the particles and the resulting solution diffuses from the dispersed particles, assuring that no solid drug, which is more irritating, contacts the mu- cosal tissue. A number of embodiments of the dosage form utilizing different drugs are exemplified and the benefits are ex- plained. Aspirin is one example.

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