Alkyl-substituted polymers having enhanced albumin affinity

Details Alkyl-substituted polymers having enhanced albumin affinity Alkyl-substituted polymers having enhanced albumin affinity

C - Chemistry, Metallurgy

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402/2, 260/213,

C08G 69/46 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 33/00 (2006.01) C08G 18/71 (2006.01) C08J 7/12 (2006.01)

Patent

CA 1206961

ALKYL-SUBSTITUTED POLYMERS HAVING ENHANCED ALBUMIN AFFINITY ABSTRACT Methods and compositions are provided for selectively enhancing the affinity of albumin for the surface of polymeric materials. Reactive non-ionic, hydrophobic aliphatic chains, in particular C14 to C20 straight chained aliphatic hydrocarbon moieties are covalently attached directly to polymeric materials such as polyamides, polyesters, polyacrylamides, and poly- urethanes. Reactive aliphatic compounds include alkyl halides, alkyl sulfonates, alkyl isocyanates, and alkyl amines. Al- ternatively, intermediate bifunctional arms, e.g. toluene- diisocyanate, can be used to link the alkyl chains to the meric polymer precursors which, following polymerization, axe available for albumin binding without postpolymerization modification. The resulting compositions when implemented in conjunction with blood products selectively enhance albumin surface affinity- binding to the exclusion of other blood components, and subsequent thrombus formation is prevented.

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