Alkyl thiazole carbamate derivatives, preparation thereof,...

Details Alkyl thiazole carbamate derivatives, preparation thereof,... Alkyl thiazole carbamate derivatives, preparation thereof,...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/427 (2006.01) A61K 31/4535 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61P 1/00 (2006.01) A61P 1/08 (2006.01) A61P 9/00 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 211/26 (2006.01) C07D 213/74 (2006.01) C07D 277/24 (2006.01)

Patent

CA 2731789

Compound of general formula (I), in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy or NR8R9 group, n is an integer equal to 1, 2 or 3, and m is an integer equal to 1 or 2, A is a covalent bond or a C1-8-alkylene group; R1 is an optionally substituted aryl or heteroaryl group, R3 is a hydrogen or fluorine atom, a C1-6-alkyl group or a trifluoromethyl group, and R4 is an optionally substituted thiazole, in the form of a base or of an acid addition salt. Therapeutic use.

Composé répondant à la formule générale (I) : dans laquelle R2 représente un atome d'hydrogène, de fluor ou un groupe hydroxyle, cyano, trifluorométhyle, C1-6-alkyle, C Image 1-6- alcoxy, NR8R9; n représente un nombre entier égal à 1, 2 ou 3 et m représente un nombre entier égal à 1 ou 2; A représente une liaison covalente ou un groupe C1-8-alkylène; R1 représente un groupe de type aryle ou hétéroaryle éventuellement substitué; R3 représente un atome d'hydrogène, de fluor, un groupe C1-6-alkyle ou un groupe trifluorométhyle; R4 représente un thiazole éventuellement substitué; à l'état de base ou de sel d'addition à un acide. Application en thérapeutique.

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