Alkylamides of carboxyalkanoyl peptides

Details Alkylamides of carboxyalkanoyl peptides Alkylamides of carboxyalkanoyl peptides

C - Chemistry, Metallurgy

07

K

530/5.04

C07K 5/04 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/083 (2006.01)

Patent

CA 1238902

ABSTRACT OF THE DISCLOSURE: The invention is related to alkylamides of carboxyalkanoyl peptides, novel compounds with notable inhibition of elastase, of general formula Image wherein R is alkyl having 1 to 5 carbon atoms or aralkyl, namely phenylethyl, A is a residue of peptidically bound proline or alanine, B is straight bond or a residue of peptidically bound proline or alanine, and X is a methylene chain having 1 to 3 carbon atoms or the -CH=CH- group. The invention is related to a process for produc- ing the novel compounds mentioned as well. The results of pharmacologic testing of these compounds allow to expect the possibility of their pharmacotherapeutic application.

408760

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