C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/272, 260/578
C07C 225/22 (2006.01) A61K 31/135 (2006.01) C07C 45/00 (2006.01) C07C 45/45 (2006.01) C07C 49/233 (2006.01) C07C 49/80 (2006.01) C07C 217/86 (2006.01) C07C 225/16 (2006.01)
Patent
CA 2032176
- 1 - ABSTRACT Alkylamino- and alkylaminoalkyl diarylketones, a process for their preparation and their use as medicaments This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula Image where Ar is aryl of the formula Image , where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF3, NO2 and u is an integer of 1 to 3; X and Y are independently CH2-, -CF2- or -CHF-; Z and W are independently -CH2, -O-, -CHOH-, or -CHF-; m, n, p, q and t are integers which are independently 0 or 1; R1 is H or loweralkyl; R2 and R3 are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.
Allen Richard C.
Freed Brian
Hamer Russell R. L.
Allen Richard C.
Bereskin & Parr
Freed Brian
Hamer Russell R. L.
Hoechst-Roussel Pharmaceuticals Inc.
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