C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
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C07D 215/36 (2006.01) C07D 209/30 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 235/22 (2006.01) C07D 261/10 (2006.01) C07D 277/36 (2006.01) C07D 307/64 (2006.01) C07D 307/82 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 1335378
Disclosed are new aminoalkoxyphenyl derivatives of formula: Image (1) in which B is -S-, -SO- or -SO2-, R1 and R2 each are hydrogen, methyl, ethyl or halogen; A is an alkylene or 2- hydroxypropylene radical; R3 is hydrogen or alkyl; R4 is hydrogen or alkyl or R3 and R4 together form an alkylene or alkenylene optionally substituted or interrupted; Cy represents a group of formula: Image or Image or (D) (E) Image or Image or (F) (G) Image (H) R is hydrogen, alkyl, cycloalkyl,benzyl or phenyl; R5 and R6 together with the carbon atoms to which they are attached form a mono- or di-cyclic carbocyclic group; an aromatic 5- membered heterocyclic group or an aromatic 6- to 10-membered mono- or di-cyclic heterocyclic group; R7 and R8 each are hydrogen, alkyl or phenyl or together form an aromatic 6- membered carbocyclic ring; R9 is O or S; R10 is 0, S or -N-R11, and R12 and R13, each are hydrogen, alkyl or benzoyl, with the proviso that Cy does not represent a 1- indolizinyl, benzo ¦b¦ furyl or benzo ¦b¦ thienyl group, as well as the N-oxide derivatives and their pharmaceutically acceptable salts. These derivatives are useful for the treatment of angina pectoris, hypertension, arrhythma and cerebral circulatory insufficiency. They are also useful as potentiators of anti cancer drugs.
574001
Chatelain Pierre
Gubin Jean
Inion Henri
Lucchetti Jean
Mahaux Jean-Marie
Robic
Sanofi
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