Alkylated cyclic amides

Details Alkylated cyclic amides Alkylated cyclic amides

C - Chemistry, Metallurgy

07

D

260/315.05

C07D 233/78 (2006.01) C07D 233/76 (2006.01) C07D 233/86 (2006.01)

Patent

CA 1124731

ABS Compounds of the formula 1 : (I) Image wherein X is 0 or S, Rl is hydrogen, or CO2Rl represents an ester group in which the R1 moiety contains from 1 - 12 carbon atoms: R2 is hydrogen or Cl 4 alkyl, R4 is Cl g alkyl, C3 8 cycloalkyl or C3-8 cycloalkyl-Cl 6 alkyl; or R2 and R4 taken with the carbon atom to which they are joined represent a C5-8 cycloalkyl group; and R5 is Cl-6 alkyl; and salts thereof, having similar activity to natural prostaglandins, a process for their preparation, intermediates useful in that process and pharmaceutical compositions containing them.

320058

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