Alkylated pregnanes and process for obtaining same

Details Alkylated pregnanes and process for obtaining same Alkylated pregnanes and process for obtaining same

C - Chemistry, Metallurgy

07

J

260/81, 260/9

C07J 7/00 (2006.01) C07J 9/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 1050529

Abstract of the Disclosure The invention relates to novel 21-alkylated steroids of the pregnane series having the formula: Image , wherein X = H or halogen; Y = H2, H(OH), H(Cacyl), O or H(halogen); R1 = an alkyl group having 1-4 C-atoms; 22 = R1 or H; R3 = H, CH3 or halogen; Z = OH, Oalkyl or Oacyl or form together with R4 a group as indicated below; Q = (when C15-C16 is saturated) alkylidene having 1-4 C- atoms or (.beta.H)(.alpha.R4), in which R4 together with Z is alkyl- idenedioxy having 3-5 C-atoms, alkylidene having 1-4 C- atoms, aralkylidene having 7-8 C-atoms, alkylene of the formula Image , wherein A = H or halogen and B = H, halogen, alkyl (1-4 C), haloalkyl, alkoxy or phenyl, or a [17.alpha.,16.alpha.-d]- or [16.alpha.,17.alpha.-d]-oxazolino-group, wherein the C-atom in 2'-position may be substituted by alkyl (1-4 C) or phenyl; or Q = (when C15-C16 is unsaturated) methyl or halomethyl, and a process for obtaining same. The novel compounds possess strong anti-inflammatory conditions especially those associated with the skin and allergic reactions.

204503

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