Alkylated pregnanes, processes for their preparation and...

Details Alkylated pregnanes, processes for their preparation and... Alkylated pregnanes, processes for their preparation and...

C - Chemistry, Metallurgy

07

J

195/19, 260/85

C07J 9/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 1160623

ABSTRACT The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: Image wherein R1 = alkyl (1-4 C); R2 = carboxyacyl (1-18 C); X = H, F or Cl; Y = O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory propertles, when applied locally and cause little or no systemic, thymolytic, adrenolytic and salt-retaining effects.

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