Alkylation of azaglycine derivatives

Details Alkylation of azaglycine derivatives Alkylation of azaglycine derivatives

C - Chemistry, Metallurgy

07

C

C07C 281/06 (2006.01) C07D 207/16 (2006.01) C07D 209/26 (2006.01) C07D 213/42 (2006.01) C07D 213/56 (2006.01) C07D 233/64 (2006.01) C07D 333/24 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01)

Patent

CA 2059909

A process for the preparation of alkylated azaglycine derivatives of the formula I X-(A) n-N(R)-NH-CO-NH2, (I) is described in which X is an amino protective group, C1-C8-alkanoyl, C6-C14-arylcarbonyl or C6-C14-aryl-C1-C4- alkanoyl, A is amino acid or imino acid radicals optionally protected on the third function, n is 0-10, X being C1-C8-alkanoyl, C8-C14-arylcarbonyl or C6-C14-aryl- C1-C4-alkanoyl if n = 0, and R is C1-C8-alkyl, C6-C14-aryl- C1-C4-alkanoyl or C5-C12-heteroaryl-C1-C4-alkanoyl, which comprises reacting a compound of the formula X-(A)n-NH- NH-CO-NH2, in which X, A and n have the abovementioned meanings, with a primary or secondary alcohol and excess DEAD, and a tri-C1-C6-alkylphosphine, tri-C6-C14-aryl- phosphine or pyridyl-di-C6-C14-arylphosphine, it being possible for the aryl moiety to be optionally substituted by di-C1-C4-alkylamino, in an ether at 0°C to 30°C and optionally removing the amino protective group X, with the proviso that X is not Fmoc when tri-n-butylphosphine is used.

Affiliated with

Also associated with

Rating

Alkylation of azaglycine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkylation of azaglycine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkylation of azaglycine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1572726