C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/32 (2006.01)
Patent
CA 2628040
This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.
La présente invention porte sur un nouveau dérivé d'alkylcarbamoylnaphtalényloxyocténoylhydroxyamide de formule (1) pouvant être employé pour inhiber l'activité enzymatique de l'histone désacétylase, ce qui permet de supprimer efficacement la prolifération de cellules cancéreuses. La présente invention porte également sur une méthode de synthèse dudit composé et sur une préparation pharmaceutique le comprenant.
Cho Joong Myung
Hyun Young Lan
Jeong Won Jang
Jung Hee Jung
Kim Jae Hak
Cassan Maclean
Crystalgenomics Inc.
Korea Research Institute Of Chemical Technology
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